Pharmacology is a science that embodies the discovery and understanding of agents that modify physiological processes for the benefit of the host organism. Most of the research in Pharmacology has classically involved characterization of existing therapeutic agents with respect to their chemical structure, therapeutic and toxic effects, and their mechanism(s) of action and biodisposition. New drugs have been discovered largely by random screening or by chemical modification of existing agents. The MTTP curriculum is designed to stimulate students to use multiple, and often simultaneous, approaches to general biological, and specific pharmacological, problems. Particular emphasis is placed on molecular and biotechnological approaches. It is important that Ph.D. students have a sufficient grounding in classical pharmacological principles and therapeutics to understand the broader clinical application of drugs. However, the ultimate measure of a pharmacologist is the ability to identify, within the context of a biological problem, the potential for developing new therapeutic strategies. Fundamentally, the approach is an active one, i.e., "how can the data, biological system, or technology be used to design new therapeutic approaches to pathophysiological problems?"