The Department of Psychosis Studies is one of the world’s largest research groups focused on psychosis, comprising over 100 staff. These include leading academics with expertise in the application of genetics, epidemiology, psychopathology, neuroimaging, cognition, and psychopharmacology in this field. The Department has received the highest possible rating in the UK Research Assessment Exercise (5*and 4*) in the last two reviews 2001 and 2008, and attracts students and staff from all over the world. The research carried out by the Department is focused on understanding the causes of psychosis and the mechanisms underlying psychosis, and includes work on all forms of psychosis, including subclinical symptoms, high risk groups, and schizophrenia and bipolar disorder. The direct integration of this research activity with high quality clinical services for psychosis ensures that clinical practice is informed by the latest research findings, and that research and teaching reflect current clinical priorities.