The Immunology program at Roswell Park Cancer Institute, University at Buffalo, prepares students for successful careers as independent investigators in cellular, molecular, and tumor immunology. The Program is multidisciplinary and highly interactive.The Department of Immunology has ongoing research programs in many aspects of immunology with an emphasis on understanding why immune responses are generally ineffective against malignant cells in cancer patients, directly coupled with efforts to therapeutically elicit more potent anti-tumor immunity. This is being done through collaborative research programs that are grouped into 4 major areas of focus: Identifying the molecular mechanisms by which tumor cells become resistant to immune recognition and killing; Characterizing the molecular and cellular elements of the tumor microenvironment that influence tumor cell growth and immune control; Designing of new strategies to enhance active specific immunotherapy; and Translation of novel laboratory findings into investigator-initiated clinical trials.